2. Signaling Pathways
  3. GPCR/G Protein
  4. Neuropeptide B/W Receptor

Neuropeptide B/W Receptor

Neuropeptide B and W (NPB and NPW) have been identified as endogenous ligands of two G-protein-coupled receptors, neuropeptides B/W receptor 1 (NPBWR1, formerly known as GPR7) and neuropeptides B/W receptor 2 (NPBWR2, formerly known as GPR8). Both neuropeptides B and W take a part in the central regulation of neuroendocrine axes, feeding behavior, energy homeostasis, cardiovascular functions, circadian rhythm, pain sensation, modulation of inflammatory pain, and emotions.

Neuropeptide B/W Receptor Related Products (7):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-108624
    CYM 50769
    		Inhibitor 98.68%
    CYM 50769 is a non-peptidic selective antagonist of neuropeptides B and W receptor 1 (NPBWR1). CYM 50769 can attenuates the NPW-23-induced cell proliferation in ATDC5. CYM 50769 can be used for researching endochondral bone formation.
    CYM 50769
  • HY-P1035
    Neuropeptide W-23 (human)
    		Agonist 99.84%
    Neuropeptide W-23 (human) (NPW-23), the active form of Neuropeptide W, is an endogenous agonist of NPBW1 (GPR7) and NPBW2 (GPR8).
    Neuropeptide W-23 (human)
  • HY-P4414
    (Des-Bromo)-Neuropeptide B (1-23) (human)
    		Agonist
    (Des-Bromo)-Neuropeptide B (1-23) (human) is an orphan G-protein coupled receptor agonist with Kis of 1.2 nM and 341 nM for GPR7 (NPBW1) and GPR8 (NPBW2), respectively.
    (Des-Bromo)-Neuropeptide B (1-23) (human)
  • HY-P3844
    Biotinyl-neuropeptide W-23 (human)
    		Agonist
    Biotinyl-neuropeptide W-23 (human) is a biotinylated neuropeptide W-23 (human) (HY-P1035). Neuropeptide W-23 (human) is an agonist of NPBW1 (GPR7) and NPBW2 (GPR8).
    Biotinyl-neuropeptide W-23 (human)
  • HY-P1035A
    Neuropeptide W-23 (human) TFA
    		Agonist
    Neuropeptide W-23 (human) (NPW-23) TFA, the active form of Neuropeptide W, is an endogenous agonist of NPBW1 (GPR7) and NPBW2 (GPR8).
    Neuropeptide W-23 (human) TFA
  • HY-P10287
    Neuropeptide W-30 (human)
    		Agonist
    Neuropeptide W-30 (human) is an important stress mediator in the central nervous system that modulates the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. Neuropeptide W-30 (human) is an endogenous ligand for the two structurally related orphan G-protein-coupled receptors (GPCRs) GPR7 and GPR8. Neuropeptide W-30 (human) activates and binds to both GPR7 and GPR8 at similar effective doses.
    Neuropeptide W-30 (human)
  • HY-P10289
    Neuropeptide W-30 (rat)
    		Agonist
    Neuropeptide W-30 (rat) is an important stress mediator in the central nervous system that modulates the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. Neuropeptide W-30 (rat) is an endogenous ligand for the two structurally related orphan G-protein-coupled receptors (GPCRs) GPR7 and GPR8. NPW-30 activates and binds to both GPR7 and GPR8 at similar effective doses.
    Neuropeptide W-30 (rat)